Ibrutix 140mg Capsule

Uses of Ibrutix 140mg Capsule

• Chronic Lymphocytic Leukemia
• Mantle Cell Lymphoma
• Waldenstrom's Macroglobulinemia
• Marginal Zone Lymphoma
• Chronic graft-versus-host disease (cGVHD)

How does

This medicine works by inhibiting the actions of certain abnormal proteins that cause the cancer cells to multiply. This helps in stopping the growth and spread of cancer.

Side Effects of Ibrutix 140mg Capsule

Common side effects include 

• Mouth sores
• Diarrhea
• Skin Rash
• Difficulty in breathing
• Back pain or Joint pain
• Unusual tiredness or weakness
• Muscle pain
• Dizziness
• High blood pressure
• Broken and brittle nails
• Headache
• Pale skin

Quick Suggestions:

• Take Ibrutix 140mg Capsule at the same time every day, either with or without food.
• It is advisable to stay hydrated and drink plenty of fluids while taking this medication.
• Do not skip any dose and complete the course as suggested by your doctor.
• Use an effective method of birth control to avoid pregnancy while taking this medication.
• Your doctor may get regular blood tests done to monitor your liver function and blood cell count in your blood.

Indication

Ibrutinib is used to treat certain blood cell and lymph node cancers, as well as chronic graft vs. host disease post-bone marrow transplant.

Pharmacology

Inhibits BTK enzymatic activity, blocking B-cell antigen receptor and cytokine receptor pathways.

Dosage & Administration of Ibrutix 140mg Capsule

• Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Waldenström Macroglobulinemia: 420 mg once daily
• Mantle Cell Lymphoma: 560 mg once daily
• Hepatic impairment: Adjust dose

Interaction

Individual drug interactions can vary, so it's essential to consult your doctor before starting any medication. Here are some points to consider:

• Interaction with Alcohol: The interaction with alcohol is unknown. Consult your doctor before consuming alcohol.
• Interaction with Medicine: Ibrutinib may interact with various medications, including isoniazid, verapamil, sitagliptin, erythromycin, miconazole, azathioprine, clopidogrel, aspirin, ketoconazole, and more. Discuss potential interactions with your doctor.
• Disease Interactions:
  • Atrial Fibrillation: Caution is advised if you have atrial fibrillation or cardiac diseases, as there might be an increased risk of worsening your condition.
  • Liver Impairment: Use caution in patients with mild to moderate liver impairment, and close monitoring of liver function is recommended.
  • Lung Toxicity: If you have a history of interstitial lung disease, watch for new or progressive pulmonary symptoms. Monitoring lung function is essential.
  • Kidney Impairment: Be cautious if you have mild to moderate kidney impairment, with close monitoring of kidney function.
  • Tumor Lysis Syndrome: Be aware of the increased risk of tumor lysis syndrome, especially if you have electrolyte abnormalities and kidney diseases.
• Food Interactions: Avoid grapefruit, grapefruit juice, and Seville oranges as they might cause adverse effects like irregular heart rhythm, diarrhea, nausea, and more.
• Lab Interactions: Specific lab interactions are not provided.

Remember, this isn't a complete list of interactions, and it's crucial to consult your doctor about the medications you're taking to ensure safety and effectiveness.

Contraindications

• Hypersensitivity
• Concomitant use with St. John's wort-containing preparations

Pregnancy & Lactation

Precautions & Warnings

• Monitor bleeding, infections, blood counts, atrial fibrillation, and other malignancies.
• Watch for tumor lysis syndrome.
• Caution in patients with heart, liver, and kidney disorders, seizures, visual issues, and concurrent use with certain medications.

Storage Conditions

Store at 20-25°C in a dry place. Protect from light.